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For those homozygous for A1298C, enzyme production can be reduced by up to 40%

NeuroCognitive Testing (CNS Vital Signs) CNS Vital Signs is a validated, computerized neuropsychological assessment covering a range of mental processes from simple motor performance through attention, memory, and executive functions

(4) Centrifuge for 10 min (12000 rpm, 4C), aspirate 150 L of the supernatant with a syringe, filter it using a 0.22 m organic phase pinhole filter, transfer it to an LC injection vial and store it at -80C until LC-MS analysis

doi: 10.1186/s13052-022-01396-2 141

examined the effective dosing range of low-dose naltrexone (LDN) in patients with chronic musculoskeletal pain