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It is possible that stimulation of the cerebello-thalamo-cortical loop earlier could modulate cerebellar activity and alter the structural and degenerative changes seen in the ET cerebellum

The elevation of extracellular glu levels suppresses system Xc-, leading to the initiation of ferroptosis ( 3.1.1 System Xc- System Xc-is consisted of SLC7A11 (catalytic subunit) and solute carrier family 3 member 2 (SLC3A2, regulatory subunit) (Dixon et al., 2012)

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