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481 Emerging evidence indicates that the gut microbiota plays a significant role in the development of DAN

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In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

Research use therefore focuses on mechanism, target validation, and combinatorial experiments (e.g., with dietary change or NAD precursors) [14,8,9]