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In the present review, we will focus mainly on the signaling cascade of TLR4 because it is believed to be the main sensor of bacterial LPS (Ignacio et al., 2016)

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With regard to the TGF--mediated EMT pathway, several studies have mentioned that the pro-inflammatory cytokines IL-6, IL-17, and IL-22, which share this pathway, are also involved in the fibrotic mechanism of SG (53, 55, 57)

Beyond its namesake function in sleep induction, current literature suggests DSIP may play a role in modulating the hypothalamic-pituitary-adrenal (HPA) axis, potentially influencing the release of luteinizing hormone (LH) and somatotropin

Germ-free (GF) mice exhibit lower levels of IGF-1 in the liver compared to conventionally raised mice [14]