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Notably, the modulation of iron metabolism regulatory elements like TfR1, DMT1, and transferrin protein 1 can potentially sway the onset and intensity of ferroptosis

Through TULP1 knockout models in zebrafish, scientists found that TULP1 deficiency causes early-onset retinal degeneration through up-regulating ferroptosis-related genes, increasing the shrinkage of mitochondria, iron and lipid droplet deposition and reducing mitochondria cristae, and increasing the death of photoreceptors via ferroptosis (Jia et al., 2022)

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