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Tumor cells also release damage-associated molecular patterns (DAMPs) after IR, including high-mobility group box 1 (HMGB1), heat shock proteins (HSPs), and calreticulin (CRT), which mediate phagocytosis of antigen-presenting cells (APCs) and initiate tumor-specific T cell activation

Challenges and Future Directions of Nasal-Brain Delivery Despite the significant promise of nasal nano-delivery systems for CNS disease treatment, their clinical translation remains constrained by a series of complex and challenges, including concerns over long-term biological safety, difficulties in scalable and reproducible manufacturing, and the absence of clear regulatory frameworks for approval

B12 is also present in the muscles

This tree is also known as the David Elm