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N-Acetyl-L-Cysteine (NAC) is a synthetic derivative of the naturally occurring amino acid L-cysteine, featuring an attached acetyl group that significantly enhances its chemical stability, cellular absorption, and overall bioavailability

wherein F411 is substituted with either an A, C, D, E, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y

For instance, 5-HT is a neurotransmitter associated with mood and behavioral inhibition, and elevated levels can lead to increased feelings of fatigue, a phenomenon known as the central fatigue hypothesis. As shown in Figure 1b, 5-HT in the brain is metabolized from tryptophan through tryptophanase (TYH)

doi: 10.1126/sciimmunol.abf6692 154

This dynamic equilibrium is maintained by glutathione reductase, which regenerates GSH from GSSG using NADPH as a reducing agent