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Furthermore, even diagnosed patients are frequently subjected to inappropriate treatments [2, 15]

[DOI] [PubMed] [Google Scholar] 117.Logsdon G.A., Ebert P., Audano P.A., et al

doi: 10.1158/1078-0432.CCR-14-1088 64 GonsalvesWIJangJSJessenEHitosugiTEvansLAJevremovicDet al

HBx induces the degradation of the host Smc5/6 complex, which otherwise would transcriptionally silence cccDNA, but is absent from the mature virion and must be expressed de novo in freshly infected hepatocytes