glutathione s-transferase calcium signaling Transferases are Involved in Salicylic Acid-Induced Transcriptional Reprogramming Figure 2 from The Role

Meanwhile, the endogenous neurotrophic factor system, especially its members with high affinity and specificity for midbrain dopaminergic neurons, constitutes an important defense mechanism against neurodegeneration

, 18 , 32, Rudolf, J

SELENOU, selenoprotein U

GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45

3 Brain organoids as models to study the role of mitochondria in neurodevelopmental diseases Diseases caused by alterations in mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) have proven challenging to model due to their inherent complexity, particularly the difficulties in manipulating mtDNA (Schon et al., 2020)