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Xiaoxue Ke, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Microbes and Innate Immunity, a section of the journal Frontiers in Cellular and Infection Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Hyperhomocysteinemia can cause downregulation of CSE and CBS, thereby causing production of H 2 S is injury ( 2 S protection in ECs can cause endothelial dysfunction and damage, and gradually lead to HHcy-related vascular disease (96)