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2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005)

The PD-L1/PD-1 interaction inhibits critical T cell signaling pathways (e.g., PI3K/AKT/mTOR), ultimately leading to exhaustion and apoptosis of the T cells, creating an immunosuppressive shield for tumors (88, 89)

GPX4 inhibition enhances glioma radiosensitivity by inducing oxidative stress-dependent SSG and degradation of transglutaminase 2 (TGM2), impairing DNA repair 126

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The number of mice in each group is shown in Supplementary Table S1