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Ser1177 phosphorylation also increases the Ca 2+ sensitivity of the synthase, permitting CaM binding and enzyme activation at lower intracellular Ca 2+ levels (Tran et al., 2009

da Fonseca, L., V

Several of these copperbinding motifs catalyze formation of reactive oxygen species (ROS), which is believed to be involved in these proteins role in neurodegenerative disorders

Biomolecules 14 , 1198

Bead samples were immediately reduced with 10 mM TCEP (55 C for 1 h), alkylated with 18.75 mM iodoacetamide (room temperature for 30 min) and then digested from the beads with trypsin (2.5 g trypsin