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Hypermethylation of the POMC promoter leads to repression of POMC expression in non-expressing tissues

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doi: 10.1136/bjo.73.7.522 17 DelcourtCCristolJ-PTessierFLegerCLMichelFPapozLet al

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The IC 50 that caused a 50% decrease in cell viability was notably higher (0.41 M for HG-3 cells and 66.2 M for MEC-1 cells) than the concentration of CB-839 required for functional GLS-1 inhibition ( Figure 3A )