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Physicians in charge decided plasma sampling to measure plasma VPA concentrations, treatments and L-carnitine dose regimen, which included an intravenous 100 mg/kg loading dose followed by a maintenance dosing up to 3 g/day in 3 divided doses for 3 days (or until ICU discharge)

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Protective effects of acetyl-L-carnitine on cisplatin cytotoxicity and oxidative stress in neuroblastoma

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The treated groups exhibited an average improvement in this ratio of +55.1% (supplement), +39.4% (lotion), and +63.5% (combination), whereas the control group experienced a slight decrease of 3.9%