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A phase III clinical trial examining lapatinib, a dual EGFR/HER-2 tyrosine kinase inhibitor that inhibits the EGFR/HER-2 signaling pathway, has shown that lapatinib reverses resistance to trastuzumab in patients with breast cancer with trastuzumab resistance 86 ( Table 1 )

doi: 10.1371/journal.ppat.1003436 117 LeibovitzE

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We thus predicted that R503 and D504 in human MAST4 constitute the RD motif, K506 is the proximate lysine residue, D522/F523/G524 is the DFG motif, and T534 or T535 is the autophosphorylation site (Fig 4A)