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D-penicillamine, dimercaprol, and edentate calcium diphosphate (EDTA) can chelate copper and enhance its elimination by the urinary tract

22,2428,3032 In addition, drug therapy is ineffective in some patients

[17] [18] Women at higher risk (e.g., those with diabetes, epilepsy, or a previous pregnancy affected by neural tube defects) should take a higher dose of 5 mg daily on prescription