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Additionally, its interaction with nitric oxide pathways has drawn attention in studies related to vascular modulation and inflammation control

Cagrilintide, a long-acting human amylin analogue, exerts both central and peripheral effects by enhancing satiety, delaying gastric emptying, and modulating postprandial glucagon secretion, whereas semaglutide acts on GLP-1 receptors in the central nervous system and peripheral tissues to regulate appetite, glycemic control, and energy balance

This publication is part of the project ROBUST: Trustworthy AI-based Systems for Sustainable Growth with project number KICH3.LTP.20.006, which is (partly) financed by the Dutch Research Council (NWO), Philips Medical Systems Nederland B.V., and the Dutch Ministry of Economic Affairs and Climate Policy (EZK) under the program LTP KIC 2020-2023

Peer review Peer review information Communications Biology thanks the anonymous reviewers for their contribution to the peer review of this work

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