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Abbreviations ARE: antioxidant response element CS: cellular senescence GSK3: glycogen synthase 3 beta KEAP1: Kelch-like ECH(Nrf2)-associated protein-1 Nrf2: nuclear factor erythroid 2-related factor 2 p62/SQSTM: polyubiquitin-binding protein p62/sequestosome 1 ROS: reactive oxygen species SASP: senescence-associated secretory phenotype -TrCP: beta-transducin repeat containing protein References Lewis, K

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This system significantly contributes to the overall antioxidant capability of cells

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