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Over time, your brain adapts by down-regulating its own natural production and sensitivity to these chemicals, requiring you to consume more of the stimulant just to reach your normal baseline

[DOI] [PubMed] [Google Scholar] 40.Fernandes C.G., Borges C.G., Seminotti B., Amaral A.U., Knebel L.A., Eichler P., de Oliveira A.B., Leipnitz G., Wajner M

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9.8 Drugs and blood brain barrier efficiency issues The physiological properties of the blood-brain barrier (BBB) undergo significant changes during the progression of Alzheimer's disease (AD) (Table 6)