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Chesney JA, Eaton JW, Mahoney JR: Bacterial glutathione: a sacrificial defense against chlorine compounds

These parameters are illustrated schematically in Figure 32 where the volume of the beakers into which the drugs diffuse represents the volume of distribution, and the size of the outflow drain in Figures 32B and 32D represents the clearance

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This is a very important and possibly crucial biochemical mechanism, since reversible thiolation of proteins can modify their enzymatic activities (glycolytic enzymes, components of the respiratory chain, creatine kinase, carbonic anhydrase), ion and metabolite transport, gene transcription, signal transduction and cell death