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Our LRP6-proximal hits further include CDK14 which initiates Wnt signaling following activation by membrane-associated cyclin Y 34 (see Introduction), and mitogen-activated kinase 4 (MLK4), a tumor suppressor in -catenin-driven colon cancers 84 (Fig

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FIGURE 1 A systematic literature search was performed across the PubMed database for relevant studies published up to June 2025

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