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Souberbielle JC, Boutten A, Carlier MC, Chevenne D, Coumaros G, Lawson-Body E, Massart C, Monge M, Myara J, Parent X, Plouvier E, Houillier P

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This effect occurs through a ROS-dependent mild mitochondrial ribosomal stress, which in turn triggers unfolded protein responses (UPR mt ) and thermogenesis in adipose tissue, promoting a high-turnover metabolism and increase resistance to obesity in mice

These effects along with that of GH are summarized in Table 1

however, suppressing only one LDH subunit is insufficient to reduce lactate secretion due to compensatory mechanisms