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Given this, the only official ASCO recommendation is that clinicians should carefully assess the risks and benefits of chemotherapy drugs known to cause CIPN, particularly in patients with pre-existing neuropathy or conditions that increase neuropathy risk, such as diabetes or a family history of neuropathy

Additional fusion proteins were developed and used: e.g., glutathione S-transferase (GST), chitin-binding domain (CBD) and small peptide tags such as polyhistidines (poly-His), FLAG octapeptides, S-tags, streptavidin II, and polyarginines (poly-Arg)

Belardi V, Gallagher EJ, Novosyadlyy R, LeRoith D

PCSK9 inhibitors primarily include monoclonal antibodies (e.g., alirocumab and evolocumab) and small interfering RNA (e.g., inclisiran)