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Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice

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conversely, the low GSH metabolism group exhibited specific activation of the MHC-II pathway

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- Min ph ship vi n hng t 350.000 tr ln

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E.CalderJ

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Researchers used LPS to establish a severe pneumonia mouse model, and genomic analysis confirmed that pulmonary endogenous bacteria can translocate to the brain and drive the transition of microglia and astrocytes from a resting state to an activated state via infection-associated pathways, thereby disrupting brain homeostasis [262]

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