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While the side effect toxicity is consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment and other aberrant signalling leading to apoptosis and necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, is also involved in the pathophysiology of CT organ toxicity

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The result is a sustained decline in sex steroid hormones, a state sometimes described medically as chemical castration in men or hypogonadism in both sexes

Thus, bioavailability will be 100% directly after injection, as the active substance is administered directly into the blood