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The table below summarizes some of the available treatment options that have shown potential in experimental models and their clinical status (Table 1)

Melatonin alleviates the heat stress-induced impairment of Sertoli cells by reprogramming glucose metabolism

Despite their benefits, antioxidants can have side effects

Glutathione Skin-Boosting Drips (IV Cocktails): These are the trendy beauty drips clinics advertise, mixing glutathione with vitamin C, collagen, and other antioxidants

As a result, NRF2 is freed from Keap1, with which it forms a complex, and is translocated into the nucleus where it binds to antioxidant responsive elements (AREs) in the promoters of target genes (Fig