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Furthermore, the WHO states that yearly 700,000 deaths are caused by AR diseases, which could increase to an annual 10 million by 2050 if no action is taken (WHO, 2021b)

L-arginine-rats, L-NAME-rats, L-NAME+L-arginine-rats Alone, L-arginine prolonged bleeding time (rats with amputation only) and increased the amount of bleeding (heparin-rats, warfarin-rats) while L-NAME reduced bleeding time (rats with amputation only)

The rationale for adding a fundoplication is twofold: treating preoperative GER symptoms and preventing the postoperative onset of GER