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First, the historical absence of a globally unified definition of rare diseases constrained our study scope to the top ten rare diseases with the highest R&D activity, which may not fully represent the broader spectrum of rare disease research

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This can lead to dramatic changes in muscle size and strength, but it also disrupts your body's natural hormone production

Colchicine (Colcrys, Mitigare): using the matches analogy discussed above1, using colchicine can be seen as dampening the uric acid matches. Colchicine does not lower the bodys store of uric acid, but it decreases the intensity of the bodys inflammatory reaction to these crystals

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