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17 (2) e13704

Nair, U

In: BagchiDSwaroopABagchiM, editors

Innovation Sci Technology

GSTs catalyze the conjugation of busulfan with glutathione, the main cellular antioxidant in the liver, as well as the active metabolite of cyclophosphamide.[] Glutathione S-transferase P1 (GSTP1) is a GST member encoded by a single gene located on the 11 th chromosome.[] GSTP1 constitutes the genotypes Ile/Ile wild, Ile/Val heterozygote, and Val/Val homozygote (mutant) (variant allele).[] Ile Val conversion in the codon 105 of GSTP1 results in reduced enzyme activity.[] GSTP1 reduces free oxygen radicals and thus reduces oxidative stress