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The GHK-Cu complex depends specifically on the Cu2+ oxidation state to maintain its square-planar coordination geometry

It may influence sleep-related signaling, circadian rhythms, and stress pathways in experimental models, though findings are limited to preclinical and in vitro studies

R., Dinse G

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It is FDA-approved for several conditions, including pediatric growth hormone deficiency, adult growth hormone deficiency, Turner syndrome, idiopathic short stature, AIDS-associated wasting, and short bowel syndrome, and is sold under brand names including Genotropin, Humatrope, Norditropin, Saizen, and Omnitrope