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The suboptimal dosage of sertraline showed effective pathway targeting by increasing secretion of excess serine and lowering its synthesis (Figure S8B)

Drug hormonal levels are consistently sustained above a given recommended threshold to ensure effective contraception provided the pills are diligently taken

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Plates were washed twice with ice-cold PBS, scraped, pelleted 250 g at 4 C for 3 min and treated on ice for 5 min with 4 ml of ice-cold HLB + N buffer (10 mM Tris-HCl (pH 7.5), 10 mM NaCl, 2.5 mM MgCl 2 , 0.5% NP-40, 1x phosphatase inhibitor cocktail (Sigma, P0044) and 1x protease inhibitor cocktail (Sigma, P8340))