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10.1074/mcp.RA118.000690 [DOI] [PMC free article] [PubMed] [Google Scholar] 135.Wang D, Zhao L, Zheng H, Dong M, Pan L, Zhang X, et al

and Methionine, which is similar to Inositol but also amplifies the combination

The acetyl group blocks the reactive thiol, preventing spontaneous oxidation

For example, one study found that a topical formulation with 2% glutathione improved skin brightness and reduced dark spots when used consistently over several weeks

Based on this mechanism, targeting HDAC6 to reduce EGFR activity may become a potential therapeutic strategy for the treatment of PKD (Liu et al., 2012)