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Curr Opin Genet Dev 1999

USA 106 , 1265812663 (2009)

Jun 10 2021 Taher et al., Pharmacological Reports, doi:10.1007/s43440-021-00296-2 A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome 18% lower mortality (p=0.65) , 14% lower ventilation (p=0.67) , 20% shorter ICU admission (p=0.48) , and 33% shorter hospitalization (p=0.31)

The manipulation included disrupting the precursor degradation pathways ( tnaA and sdaA ), eliminating l-glutathione degradation ( ggt and pepT ), and manipulating the intracellular ATP level (disruption of glgB )

Despite advances in antifungal monotherapy and combination strategies, critical challenges remain, such as overcoming the escalating drug resistance, optimizing individualized therapeutic regimens tailored to diverse patient populations, and improving long-term treatment efficacy to reduce recurrence and disease progression