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Our early studies demonstrated that vascular dysfunction of epineural arterioles that provide circulation to the sciatic nerve preceded slowing of nerve conduction velocity in streptozotocin-induced diabetes (92, 93)

Perhaps most concerning is the widespread alteration of androgen receptor gene methylation at 89 CpG sites, potentially modulating AR activity across multiple generations (87)

This immune response will then lead to progressive liver injury and ultimately to fibrosis by activation of hepatic stellate cells (131133)

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