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Week 1: 14 units (0.7 mg) daily Week 2: 16 units (0.8 mg) daily Week 3: 18 units (0.9 mg) daily Week 4: 20 units (1.0 mg) daily Patients using CJC 1295 ipamorelin for weight loss often see fat reduction become noticeable during month two

High-risk groups include vegans, those with pernicious anaemia or gastrointestinal conditions, and patients on long-term metformin or proton pump inhibitors

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While short-term fasting decreases serum IGF-I but does not affect GHBP (69), the triad of IGF-I deficiency, poor growth and pubertal delay/arrest in long term nutritional deficiency such as in anorexia nervosa is associated with low GHBP that is partly restored with weight gain (63)