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Conventionally, the main goal of radiotherapy has been to kill cancer cells, notwithstanding the local immunosuppression through various pathways such as vascular disruption and hypoxia, which might result in diminished recruitment of certain immune effector cells, exhaustion of effector T cells, and stimulation of regulatory T cells (321, 332334)

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Sim HJ, Cho C, Kim HE, Hong JY, Song EK, Kwon KY, et al

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If ALT or AST rises above three times the upper limit of normal, isotretinoin must be held or discontinued [2]