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Maintaining normal or near-normal blood glucose levels through intensive insulin therapy and patient education significantly reduces the risk and progression of retinopathy in both type 1 and type 2 diabetes

Mechanistically, the PR-DUB complex binds on the SLC7A11 promoter, allowing BAP1 to deubiquitinate H2Aub on the SLC7A11 promoter and subsequently repress SLC7A11 expression independent of p53 (Fig