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Recently, specific inhibitors of ACSL4 and research on its upstream transcriptional regulators such as SP1 have shown clear cartilage-protective effects in OA models, suggesting that future strategies combining GPX4 modulation to enhance defense with ACSL4 inhibition to reduce attack may achieve more potent and synergistic therapeutic outcomes (He W

Reynolds MR, Lane AN, Robertson B, Kemp S, Liu Y, Hill BG, Dean DC, Clem BF

Clinical and subjective measures Depression Depressive symptoms were assessed with the clinician-rated MontgomeryAsberg Depression Rating Scale (MADRS) as the primary measure, together with the self-report Quick Inventory of Depressive SymptomatologySelf Report (QIDSSR) and the Maudsley 3-item Depression Visual Analogue Scale (M3VAS)

HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction

Neuron 10:851863 Bossi S, Pizzamiglio L, Paoletti P (2023) Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling