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Cortisol, a glucocorticoid hormone, is known to have neurotoxic effects when present in excess

References Biomedicines (2022) Stable gastric pentadecapeptide BPC 157: pleiotropic beneficial activity and neurotransmitter interactions Current Pharmaceutical Design (2018) BPC 157 and standard angiogenic growth factors: gastrointestinal tract healing and angiogenesis Annals of the New York Academy of Sciences (2007) Thymosin 4: roles in development, repair, and regeneration Expert Opinion on Biological Therapy (2018) Thymosin 4: a multi-functional regenerative peptide

This decline correlates with slower wound healing, thinner skin, and more visible aging

Delaunay-Moisan A, Appenzeller-Herzog C

The following primary antibodies were used: anti-Sca-1 (Ly6a) (1:500, R&D Systems, #MAB1226), anti-Olfm4 (1:1000, Cell Signaling Technology, #39141), anti-Lysozyme (1:500, Dako, #A0099), anti-tdTomato (1:200, Origene, #AB8181), anti-Dclk1(1:100, Abgent, #AP7219B), anti-Chga(1:1000, Diasorin, #20085), anti-collagen I (1:200, Abcam, #ab270993) and anti-YAP(1:200, Cell signaling, #4912)