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As a system inhibitor and ferroptosis inducer, the therapeutic potential of erastin has been shown in multiple cancer types including breast cancer (130)

Hence, we present the molecular interactions and binding poses of selected flavonoids (anthocyanidin such as the cyanidin-3- O -glucoside and (/+)-catechins such as ()-epicatechin and (+)-catechin) in the catalytic pocket of mh-Tyr (in absence of mammalian tyrosinase crystal structure) using computational approaches

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Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)