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Hepatology 1995, 22: 759-766

The Inflammation Cascade Once triggered, the inflammatory response in seborrheic dermatitis follows a predictable pattern: Initial trigger: Malassezia metabolites penetrate the skin barrier Immune activation: Dendritic cells detect the "threat" and activate Signal amplification: NLRP3 inflammasome triggers IL-1 release Recruitment: More immune cells are called to the area Tissue damage: Inflammation damages skin cells, worsening barrier function Perpetuation: Damaged barrier allows more triggers to penetrate, continuing the cycle This cascade explains why seborrheic dermatitis tends to be chronic and relapsing