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Current studies have shown that NRF2 deficiency enhances the susceptibility of PC12 cells to ferroptosis

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[DOI] [PubMed] [Google Scholar] 200.Bola BM, Chadwick AL, Michopoulos F, Blount KG, Telfer BA, Williams KJ, Smith PD, Critchlow SE, Stratford IJ

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Elliott JE, Keil AT, Mithani S, Gill JM, ONeil ME, Cohen AS, et al

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Postmenopausal women are not the only group carrying disproportionate risk

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This is related to its promotion of SOD and GSH activity, upregulation of GPX4, SLC7A11, and SLC3A2 expression, reduction of malondialdehyde content and iron concentration, as well as downregulation of TFR1 expression

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