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Physiol Rev 82:4795 Bedard K, Krause KH (2007) The Nox family of ROS-generating NADPH oxidases: physiology and pathophysiology

However, there is a notable lack of formal safety data

such biologics are well tolerated and may not cause systemic immune activation

In the context of Alzheimer's disease (AD), both microglia and neighboring neural cells display a range of mitochondrial abnormalities, including: Genetic instability: The accumulation of mitochondrial DNA (mtDNA) mutations with age, which can trigger inflammation by acting as damage-associated molecular patterns (DAMPs)