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On cross-sectional gross pathology, CNs appear as a typically well-delineated white rubbery nodular lesion within the dermis, with an overlying grenz zone of normal papillary dermis, often extending into the subdermis with a barbell-like contraction at the plane of surrounding skin

Based on the relationship between IL-15 and cuproptosis-related genes, perhaps studies combining IL-15-related drugs with cuproptosis gene targets could provide new ideas and insights into the treatment of GC (158)

demonstrated that both db/db mice and cardiomyocyte models treated with high glucose presented upregulated ZFAS1 expression and increased ferroptosis, whereas ZFAS1 inhibition reduced ferroptosis in the myocardium [94]

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