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Nevertheless, the application of O 3 therapy remains controversial because of concerns about its toxicity and side effects toward the respiratory tract, headache, and gastrointestinal discomfort

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Ipamorelin is studied as a selective ghrelin mimetic it binds the growth-hormone-secretagogue receptor (GHSR-1a), the same receptor the hunger hormone ghrelin uses, and in research settings appears to stimulate GH release with relatively limited effect on other hormones such as cortisol, prolactin, and ACTH