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Cyanocobalamin is a significant regulator of homocysteine levels, which can disrupt the nutrition of the blood vessels and nerves of the retina

It is interesting, however, that evaluation of small fiber function as performed by QST (that is, thermal thresholds) did not show significant changes following ARA 290 administration

[DOI] [PubMed] [Google Scholar] 178.Fliser D., Laville M., Covic A., Fouque D., Vanholder R., Juillard L., Van Biesen W., Ad-hoc working group of ERBP A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guidelines on acute kidney injury: part 1: definitions, conservative management and contrast-induced nephropathy

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Across all clinical trials, the side effect profile was consistently described as indistinguishable from placebo