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Some commenters suggested that CMS use an alternative term to refer to these technologies, such as Software as a Medical Device in conformance with FDA definitions, or clinical decision support tools. Some commenters provided suggestions on how CMS should categorize these types of services in terms of payment

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This mini review summarizes neurotrophin biology relevant to bone sarcoma, delineates mechanisms by which these pathways reprogram immune and stromal compartments, and evaluates therapeutic strategies ranging from ligand/receptor blockade to clinically available TRK inhibitors, with the objective of defining tractable approaches to restore immune competence in this disease

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Increased concentrations of vitamin B 12 in serum (1289 pg/ml) (norm: 197771 pg/ml), folic acid (30.9 ng/ml) (norm: 3.117.5) and homocysteine (14.73 mol/l) (norm: 5.0013.90) were detected