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Among the up-regulated genes, p21 cip1 gene but not p27 kip1 gene, two important genes associated with cell cycle regulation, was found to be highly and dose-dependently expressed (Fig

Insulin sensitivity in liver, muscles, and adipose tissue was reduced in subjects with high amounts of hepatic lipids (25.3 3.5%, n = 10) compared to individuals with normal levels of hepatic lipids (3.6 0.5%, n = 10) matched for visceral adipose tissue volume [65]

Activation of mTOR leads to inhibition of autophagy [248], generally observed in ASD patients [242, 245, 251, 256]

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We selected this age range because a consensus has emerged that a professional diagnosis of autism can be carried out accurately as early at 18 months of age