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The guidelines state, However, pernicious anaemia in its true sense (that is, life-threatening anaemia) is now extremely rare because of developments in testing and treatment for, and greater awareness of, vitamin B 12 deficiency . In one sense, this statement is correct: the term pernicious anaemia, when taken literally, implies a severe, life-threatening form of anaemia, which is uncommon in modern practice due to improvements in testing and treatment, such severe manifestations are typically prevented, as the condition is more likely to be diagnosed earlier or treated with B 12

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MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

The results showed that hypoxia reduced the levels of almost all ceramide species, and this was significantly correlated with the duration of hypoxia (Fig

Voute M, Morel V, Pickering G