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Liposomal formulations partially address this

Le XH, Lee CP, Monachello D, Millar AH

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The microtubule-associated protein Tau ( MAPT ) gene, which is involved in stabilization of cytoskeleton and subsequent facilitation of the transport of neurotransmitters, has also been found as a locus associated with genetic risk for PD (Satake et al., 2009)

Another study by Xie et al showed that the high-cholesterol diet induced time-dependent alterations in endothelial-dependent and -independent vascular responses, endothelial cell density, smooth muscle-to-collagen ratio, selective phospho-endothelial NOS-Ser1177 expression, and cGMP levels in the penis of mouse model [131]